ea0029p927 | Female Reproduction | ICEECE2012
Cacciatore C.
, Bonomi M.
, Somigliana E.
, Busnelli M.
, Rossetti R.
, Paffoni A.
, Persani L.
Primary ovarian insufficiency (POI) is a critical fertility defect characterized by a progressive and silent impairment of the follicular reserve. POI aetiology is heterogeneous and largely unknown, but a maternal inheritance often characterizes idiopathic forms. Therefore, we hypothesized a possible involvement of a mitochondrial defect in the pathogenesis of this disease since mitochondrial biogenesis and bioenergetics play an essential role in ovarian folliculogenesis. Our ...